Home  |  Contact

ENZYME entry: EC

Accepted Name
L-tryptophan isonitrile synthase.
Reaction catalysed
L-tryptophan + D-ribulose 5-phosphate <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H(2)O
  • The enzymes from cyanobacteria that belong to the Stigonematales order participate in the biosynthesis of hapalindole-type alkaloids.
  • According to the proposed mechanism, the enzyme forms an imine intermediate composed of linked L-tryptophan and D-ribulose 5-phosphate, followed by loss of the phosphate group and formation of a beta-keto imine and keto-enol tautomerization.
  • This is followed by a C-C bond cleavage, the release of acetol, and a retro aldol type reaction that releases formaldehyde and forms the final product.
  • Cf. EC, L-tyrosine isonitrile synthase.
PRIAM enzyme-specific profiles4.1.99.25
KEGG Ligand Database for Enzyme Nomenclature4.1.99.25
IUBMB Enzyme Nomenclature4.1.99.25
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-