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ENZYME

ENZYME entry: EC 4.2.1.114

PURL: https://purl.expasy.org/enzyme/EC/4.2.1.114
Accepted Name
methanogen homoaconitase
Alternative Name(s)
methanogen HACN
Reaction catalysed
(2R)-homocitrate = (2R,3S)-homoisocitrate
Comment(s)
  • Catalyzes several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.
  • In contrast to EC 4.2.1.36, this enzyme can catalyze both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate.
  • In addition to cis-homoaconitate, the enzyme can also catalyze the hydration of the physiological substrates dihomoaconitate and trihomoaconitate as well as the non-physiological substrate tetrahomoaconitate.
  • cis-Aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme.
Cross-references
BRENDA4.2.1.114
EC2PDB4.2.1.114
ExplorEnz4.2.1.114
KEGG Ligand Database for Enzyme Nomenclature4.2.1.114
IUBMB Enzyme Nomenclature4.2.1.114
MEDLINEFind literature relating to 4.2.1.114
MetaCyc4.2.1.114
Rhea expert-curated reactions4.2.1.114
UniProtKB/Swiss-Prot
Q8TLF1, HACA_METACQ58409, HACA_METJAQ8PZT3, HACA_METMA
O27668, HACA_METTHQ8TJM9, HACB1_METACQ8TRF7, HACB2_METAC
Q58667, HACB_METJAQ8PZ49, HACB_METMAO26917, HACB_METTH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-