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ENZYME entry: EC 4.2.1.136

Accepted Name
ADP-dependent NAD(P)H-hydrate dehydratase
Alternative Name(s)
(6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolyzing; NADH-forming)
(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolyzing)
Reaction catalysed
  • (6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate
  • (6S)-NADPHX + ADP <=> AMP + H(+) + NADPH + phosphate
Comment(s)
  • Acts equally well on hydrated NADH and hydrated NADPH.
  • NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers.
  • The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC 5.1.99.6), while the other catalyzes the dehydration.
  • Hence the enzyme can restore the complete mixture of isomers into NAD(P)H.
  • The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC 4.2.1.93).
Cross-references
BRENDA4.2.1.136
EC2PDB4.2.1.136
ExplorEnz4.2.1.136
PRIAM enzyme-specific profiles4.2.1.136
KEGG Ligand Database for Enzyme Nomenclature4.2.1.136
IUBMB Enzyme Nomenclature4.2.1.136
IntEnz4.2.1.136
MEDLINEFind literature relating to 4.2.1.136
MetaCyc4.2.1.136
Rhea expert-curated reactions4.2.1.136
UniProtKB/Swiss-Prot
P94368, NNRD_BACSUQ7VU32, NNRD_BORPEA0RU82, NNRD_CENSY
Q833Y3, NNRD_ENTFAA6GXW4, NNRD_FLAPJD2RXF6, NNRD_HALTV
Q9CIU7, NNRD_LACLAF9UN92, NNRD_LACPLQ8Y6R2, NNRD_LISMO
D3SQW0, NNRD_NATMMQ5F8G9, NNRD_NEIG1Q9JRZ9, NNRD_NEIMB
A9A498, NNRD_NITMSQ7UFW7, NNRD_RHOBAQ2G2P8, NNRD_STAA8
Q8DQD2, NNRD_STRR6P96051, NNRD_STRTRQ8PBP3, NNRD_XANCP
O67377, NNR_AQUAEO29407, NNR_ARCFUQ8NSS3, NNR_CORGL
Q83CM5, NNR_COXBUB8E2P6, NNR_DICTDP31806, NNR_ECOLI
Q7NIE6, NNR_GLOVIQ9ZJM4, NNR_HELPJP56176, NNR_HELPY
A2BLC0, NNR_HYPBUB1L3W1, NNR_KORCOA4H7T9, NNR_LEIBR
A4HW65, NNR_LEIINQ4QFL5, NNR_LEIMAQ2FT57, NNR_METHJ
Q58981, NNR_METJAQ8TX67, NNR_METKAO27324, NNR_METTH
Q2RGI2, NNR_MOOTAP37391, NNR_MYCLEP9WF10, NNR_MYCTO
P9WF11, NNR_MYCTUQ8ZV04, NNR_PYRAEQ2S580, NNR_SALRD
P74217, NNR_SYNY3D1BAA5, NNR_THEASQ9X024, NNR_THEMA
A1S0R2, NNR_THEPDQ8DGC3, NNR_THEVBB5YIM0, NNR_THEYD
Q9KMX5, NNR_VIBCH

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