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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.3.2.8

Accepted Name
Gamma-glutamylamine cyclotransferase.
Reaction catalysed
Epsilon-(gamma-L-glutamyl)-L-lysine <=> L-lysine + 5-oxo-L-proline
Comment(s)
  • The enzyme, found in vertebrates, has no activity toward alpha- (gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9).
  • The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
Cross-references
BRENDA4.3.2.8
EC2PDB4.3.2.8
ExplorEnz4.3.2.8
PRIAM enzyme-specific profiles4.3.2.8
KEGG Ligand Database for Enzyme Nomenclature4.3.2.8
IUBMB Enzyme Nomenclature4.3.2.8
IntEnz4.3.2.8
MEDLINEFind literature relating to 4.3.2.8
MetaCyc4.3.2.8
UniProtKB/Swiss-Prot
A0JMM9, GGACA_DANRE;  Q66I06, GGACB_DANRE;  A3KNL6, GGACC_DANRE;  
Q0VFX9, GGACT_BOVIN;  Q9BVM4, GGACT_HUMAN;  Q923B0, GGACT_MOUSE;  
Q4KM86, GGACT_RAT;  Q66KX0, GGACT_XENLA;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-