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ENZYME

ENZYME entry: EC 6.3.1.9

Accepted Name
trypanothione synthase
Alternative Name(s)
TSR synthetase
Reaction catalysed
  • ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate
  • ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione
Comment(s)
  • The enzyme, characterized from several trypanosomatids (e.g. Trypanosoma cruzi) catalyzes two subsequent reactions, leading to production of trypanothione from glutathione and spermidine.
  • Some trypanosomatids (e.g. Crithidia species and some Leishmania species) also contain an enzyme that only carries out the first reaction (cf. EC 6.3.1.8).
  • The enzyme is bifunctional, and also catalyzes the hydrolysis of glutathionylspermidine and trypanothione (cf. EC 3.5.1.78).
Cross-references
BRENDA6.3.1.9
EC2PDB6.3.1.9
ExplorEnz6.3.1.9
PRIAM enzyme-specific profiles6.3.1.9
KEGG Ligand Database for Enzyme Nomenclature6.3.1.9
IUBMB Enzyme Nomenclature6.3.1.9
IntEnz6.3.1.9
MEDLINEFind literature relating to 6.3.1.9
MetaCyc6.3.1.9
Rhea expert-curated reactions6.3.1.9
UniProtKB/Swiss-Prot
O60993, TRYS_CRIFAQ9GT49, TRYS_TRYCC

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