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ENZYME entry: EC 6.3.1.9

Accepted Name
Trypanothione synthase.
Alternative Name(s)
TSR synthetase.
Reaction catalysed
  • Glutathione + spermidine + ATP <=> glutathionylspermidine + ADP + phosphate
  • Glutathione + glutathionylspermidine + ATP <=> N(1),N(8)-bis(glutathionyl)spermidine + ADP + phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme, characterized from several trypanosomatids (e.g. Trypanosoma cruzi) catalyzes two subsequent reactions, leading to production of trypanothione from glutathione and spermidine.
  • Some trypanosomatids (e.g. Crithidia species and some Leishmania species) also contain an enzyme that only carries out the first reaction (cf. EC 6.3.1.8).
  • The enzyme is bifunctional, and also catalyzes the hydrolysis of glutathionylspermidine and trypanothione (cf. EC 3.5.1.78).
Cross-references
PROSITEPDOC50975
BRENDA6.3.1.9
EC2PDB6.3.1.9
ExplorEnz6.3.1.9
PRIAM enzyme-specific profiles6.3.1.9
KEGG Ligand Database for Enzyme Nomenclature6.3.1.9
IUBMB Enzyme Nomenclature6.3.1.9
IntEnz6.3.1.9
MEDLINEFind literature relating to 6.3.1.9
MetaCyc6.3.1.9
UniProtKB/Swiss-Prot
O60993, TRYS_CRIFA;  Q9GT49, TRYS_TRYCC;  

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