ENZYME entry: EC 6.3.1.9
| Accepted Name |
|---|
| Trypanothione synthase.
|
| Alternative Name(s) |
|---|
| TSR synthetase. |
| Reaction catalysed |
|---|
- Glutathione + spermidine + ATP <=> glutathionylspermidine + ADP + phosphate
- Glutathione + glutathionylspermidine + ATP <=> N(1),N(8)-bis(glutathionyl)spermidine + ADP + phosphate
|
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- The enzyme, characterized from several trypanosomatids (e.g.
Trypanosoma cruzi) catalyzes two subsequent reactions, leading to
production of trypanothione from glutathione and spermidine.
- Some trypanosomatids (e.g. Crithidia species and some Leishmania
species) also contain an enzyme that only carries out the first
reaction (cf. EC 6.3.1.8).
- The enzyme is bifunctional, and also catalyzes the hydrolysis of
glutathionylspermidine and trypanothione (cf. EC 3.5.1.78).
|
| Cross-references |
|---|
| PROSITE | PDOC50975 |
| BRENDA | 6.3.1.9 |
| EC2PDB | 6.3.1.9 |
| ExplorEnz | 6.3.1.9 |
| PRIAM enzyme-specific profiles | 6.3.1.9 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.1.9 |
| IUBMB Enzyme Nomenclature | 6.3.1.9 |
| IntEnz | 6.3.1.9 |
| MEDLINE | Find literature relating to 6.3.1.9 |
| MetaCyc | 6.3.1.9 |
| UniProtKB/Swiss-Prot |
|
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