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ENZYME entry: EC 6.3.4.15

Accepted Name
biotin--[biotin carboxyl-carrier protein] ligase.
Alternative Name(s)
acetyl-CoA carboxylase biotin holoenzyme synthetase.
biotin--[acetyl-CoA-carboxylase] ligase.
biotin--[acetyl-CoA carboxylase] synthetase.
biotin--protein ligase.
Reaction catalysed
ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]
Comment(s)
  • The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14.
  • The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15.
  • In some organisms the carrier protein is part of EC 6.4.1.2.
Cross-references
BRENDA6.3.4.15
EC2PDB6.3.4.15
ExplorEnz6.3.4.15
PRIAM enzyme-specific profiles6.3.4.15
KEGG Ligand Database for Enzyme Nomenclature6.3.4.15
IUBMB Enzyme Nomenclature6.3.4.15
IntEnz6.3.4.15
MEDLINEFind literature relating to 6.3.4.15
MetaCyc6.3.4.15
Rhea expert-curated reactions6.3.4.15
UniProtKB/Swiss-Prot
Q5F5C8, BICOA_NEIG1;  Q9JWI7, BICOA_NEIMA;  Q9JXF1, BICOA_NEIMB;  
E0U174, BIRA_BACSH;  P0CI75, BIRA_BACSU;  P06709, BIRA_ECOLI;  
P46363, BIRA_HAEIN;  I6YFP0, BIRA_MYCTU;  P29906, BIRA_PARDE;  
P37416, BIRA_SALTY;  P50747, BPL1_HUMAN;  Q920N2, BPL1_MOUSE;  
O14353, BPL1_SCHPO;  P48445, BPL1_YEAST;  Q59014, BPL_METJA;  
Q9SL92, HCS1_ARATH;  

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