ENZYME entry: EC 6.3.4.15
Accepted Name |
Biotin--[biotin carboxyl-carrier protein] ligase.
|
Alternative Name(s) |
Acetyl-CoA carboxylase biotin holoenzyme synthetase. |
Biotin--[acetyl-CoA carboxylase] synthetase. |
Biotin--[acetyl-CoA-carboxylase] ligase. |
Biotin--protein ligase. |
Reaction catalysed |
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine <=> AMP + diphosphate + [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine |
Comment(s) |
- The enzyme biotinylates a biotin carboxyl-carrier protein that is
part of an acetyl-CoA carboxylase complex, enabling its subsequent
carboxylation by EC 6.3.4.14.
- The carboxyl group is eventually transferred to acetyl-CoA by
EC 2.1.3.15.
- In some organisms the carrier protein is part of EC 6.4.1.2.
|
Cross-references |
BRENDA | 6.3.4.15 |
EC2PDB | 6.3.4.15 |
ExplorEnz | 6.3.4.15 |
PRIAM enzyme-specific profiles | 6.3.4.15 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.4.15 |
IUBMB Enzyme Nomenclature | 6.3.4.15 |
IntEnz | 6.3.4.15 |
MEDLINE | Find literature relating to 6.3.4.15 |
MetaCyc | 6.3.4.15 |
Rhea expert-curated reactions | 6.3.4.15 |
UniProtKB/Swiss-Prot |
Q5F5C8, BICOA_NEIG1; | Q9JWI7, BICOA_NEIMA; | Q9JXF1, BICOA_NEIMB; |
E0U174, BIRA_BACSH; | P0CI75, BIRA_BACSU; | P06709, BIRA_ECOLI; |
P46363, BIRA_HAEIN; | I6YFP0, BIRA_MYCTU; | P29906, BIRA_PARDE; |
P37416, BIRA_SALTY; | P50747, BPL1_HUMAN; | Q920N2, BPL1_MOUSE; |
O14353, BPL1_SCHPO; | P48445, BPL1_YEAST; | Q59014, BPL_METJA; |
Q9SL92, HCS1_ARATH; |
|
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