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ENZYME entry: EC 6.3.5.12

Accepted Name
Ni-sirohydrochlorin a,c-diamide synthase.
Reaction catalysed
2 ATP + Ni-sirohydrochlorin + 2 L-glutamine + 2 H(2)O <=> 2 ADP + 2 phosphate + Ni-sirohydrochlorin a,c-diamide + 2 L-glutamate
Comment(s)
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel- containing tetrapyrrole cofactor coenzyme F(430), which is required by EC 2.8.4.1.
Cross-references
BRENDA6.3.5.12
EC2PDB6.3.5.12
ExplorEnz6.3.5.12
PRIAM enzyme-specific profiles6.3.5.12
KEGG Ligand Database for Enzyme Nomenclature6.3.5.12
IUBMB Enzyme Nomenclature6.3.5.12
IntEnz6.3.5.12
MEDLINEFind literature relating to 6.3.5.12
MetaCyc6.3.5.12
Rhea expert-curated reactions6.3.5.12
UniProtKB/Swiss-Prot
Q8TK00, CBIA_METAC;  Q46FL0, CBIA_METBF;  Q58816, CBIA_METJA;  
A4FW46, CBIA_METM5;  A6VH63, CBIA_METM7;  A5UMJ2, CBIA_METS3;  
Q2NHQ3, CBIA_METST;  O27509, CBIA_METTH;  A6UQC1, CBIA_METVS;  

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