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ENZYME entry: EC 6.3.5.9

Accepted Name
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)
Reaction catalysed
2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate
Comment(s)
  • This enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, generates hydrogenobyrinate a,c-diamide, the substrate required by EC 6.6.1.2 which adds cobalt to the macrocycle.
  • The equivalent reaction in the anaerobic cobalamin biosynthesis pathway is catalyzed by EC 6.3.5.11.
Cross-references
BRENDA6.3.5.9
EC2PDB6.3.5.9
ExplorEnz6.3.5.9
PRIAM enzyme-specific profiles6.3.5.9
KEGG Ligand Database for Enzyme Nomenclature6.3.5.9
IUBMB Enzyme Nomenclature6.3.5.9
IntEnz6.3.5.9
MEDLINEFind literature relating to 6.3.5.9
MetaCyc6.3.5.9
Rhea expert-curated reactions6.3.5.9
UniProtKB/Swiss-Prot
Q8UBQ8, COBB_AGRFCA6X051, COBB_BRUA4Q57CK2, COBB_BRUAB
Q8YHU1, COBB_BRUMEA5VR62, COBB_BRUO2Q8G020, COBB_BRUSU
P63836, COBB_MYCBOP9WP96, COBB_MYCTOP9WP97, COBB_MYCTU
Q9I471, COBB_PSEAEQ98KP1, COBB_RHILOQ92P48, COBB_RHIME
O68108, COBB_RHOCBP21632, COBB_SINSXQ9RJ16, COBB_STRCO
A4VJ35, COBB_STUS1Q47T68, COBB_THEFY

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