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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 7.2.4.1

Accepted Name
Carboxybiotin decarboxylase.
Alternative Name(s)
Carboxybiotin protein decarboxylase.
Reaction catalysed
A carboxybiotinyl-[protein] + 1-2 Na(+)(In) + H(+)(Out) <=> CO(2) + a biotinyl-[protein] + 1-2 Na(+)(Out)
Comment(s)
  • The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 4.1.1.89.
  • The free energy of the decarboxylation reaction is used to pump Na(+) out of the cell.
  • The enzyme is a member of the Na(+)-translocating decarboxylase family, other members of which include EC 7.2.4.2 and EC 7.2.4.3.
  • Formerly EC 4.3.99.2.
Cross-references
BRENDA7.2.4.1
EC2PDB7.2.4.1
ExplorEnz7.2.4.1
PRIAM enzyme-specific profiles7.2.4.1
KEGG Ligand Database for Enzyme Nomenclature7.2.4.1
IUBMB Enzyme Nomenclature7.2.4.1
IntEnz7.2.4.1
MEDLINEFind literature relating to 7.2.4.1
MetaCyc7.2.4.1
UniProtKB/Swiss-Prot
O06923, MADB_MALRU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 7.-.-.-