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ENZYME

ENZYME entry: EC 7.2.4.1

PURL: https://purl.expasy.org/enzyme/EC/7.2.4.1
Accepted Name
carboxybiotin decarboxylase
Alternative Name(s)
carboxybiotin protein decarboxylase
Reaction catalysed
N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) + H(+) = N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out) + CO2
Comment(s)
  • The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 4.1.1.89.
  • The free energy of the decarboxylation reaction is used to pump Na(+) out of the cell.
  • The enzyme is a member of the Na(+)-translocating decarboxylase family, other members of which include EC 7.2.4.2 and EC 7.2.4.3.
  • Formerly EC 4.3.99.2.
Cross-references
BRENDA7.2.4.1
EC2PDB7.2.4.1
ExplorEnz7.2.4.1
KEGG Ligand Database for Enzyme Nomenclature7.2.4.1
IUBMB Enzyme Nomenclature7.2.4.1
MEDLINEFind literature relating to 7.2.4.1
MetaCyc7.2.4.1
Rhea expert-curated reactions7.2.4.1
UniProtKB/Swiss-Prot
O06923, MADB_MALRU

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