ENZYME entry: EC 2.1.1.113

Accepted Name
Site-specific DNA-methyltransferase (cytosine-N(4)-specific).
Alternative Name(s)
Modification methylase.
N(4)-cytosine-specific DNA methylase.
Restriction-modification system.
Reaction catalysed
S-adenosyl-L-methionine + DNA cytosine <=> S-adenosyl-L-homocysteine + DNA N(4)-methylcytosine
Comment(s)
  • This is a large group of enzymes, the majority of which, with enzymes of similar site specificity listed as EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5, form so-called restriction-modification systems.
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
Cross-references
PROSITEPDOC00088
BRENDA2.1.1.113
EC2PDB2.1.1.113
ExplorEnz2.1.1.113
PRIAM enzyme-specific profiles2.1.1.113
KEGG Ligand Database for Enzyme Nomenclature2.1.1.113
IUBMB Enzyme Nomenclature2.1.1.113
IntEnz2.1.1.113
MEDLINEFind literature relating to 2.1.1.113
MetaCyc2.1.1.113
UniProtKB/Swiss-Prot
P0A462, MTA1_ANAVA;  P0A461, MTA1_NOSS1;  P23941, MTB1_BACAM;  
O68556, MTB1_BACIU;  Q9LAI2, MTB1_BACSQ;  P70986, MTB1_GEOSE;  
P18051, MTB2_BACAM;  Q45489, MTB2_BACIU;  Q04845, MTC1_CITFR;  
P14243, MTC9_CITFR;  P29568, MTHZ_METTF;  Q58392, MTM1_METJA;  
Q58843, MTM2_METJA;  Q58893, MTM5_METJA;  Q58606, MTM6_METJA;  
P14244, MTMV_KOCVA;  O59647, MTMW_METWO;  P11409, MTP2_PROHU;  
O52692, MTS1_STRCS;  O52513, MTS1_STRFI;  P14230, MTSM_SERMA;  
P30774, MTX1_XANCC;  

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