ENZYME entry: EC 2.6.99.2

Accepted Name
Pyridoxine 5'-phosphate synthase.
Alternative Name(s)
PNP synthase.
Pyridoxine 5-phosphate phospho lyase.
Reaction catalysed
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> pyridoxine 5'-phosphate + phosphate + 2 H(2)O
Comment(s)
  • In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72, EC 1.1.1.290, EC 2.6.1.52, EC 1.1.1.262, EC 2.6.99.2 and EC 1.4.3.5.
  • 1-deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate.
Cross-references
BRENDA2.6.99.2
EC2PDB2.6.99.2
ExplorEnz2.6.99.2
PRIAM enzyme-specific profiles2.6.99.2
KEGG Ligand Database for Enzyme Nomenclature2.6.99.2
IUBMB Enzyme Nomenclature2.6.99.2
IntEnz2.6.99.2
MEDLINEFind literature relating to 2.6.99.2
MetaCyc2.6.99.2
UniProtKB/Swiss-Prot
B0C977, PDXJ_ACAM1;  Q3V7G6, PDXJ_ACIAD;  B7J9K4, PDXJ_ACIF2;  
B5EQL6, PDXJ_ACIF5;  Q8UDU5, PDXJ_AGRT5;  B9JXN7, PDXJ_AGRVS;  
B2URE7, PDXJ_AKKM8;  Q0VP22, PDXJ_ALCBS;  Q3V7J9, PDXJ_ANAMM;  
Q2GJT4, PDXJ_ANAPZ;  Q3M9L4, PDXJ_ANAVT;  O67417, PDXJ_AQUAE;  
P46212, PDXJ_AQUPY;  A8ESJ1, PDXJ_ARCB4;  Q5P083, PDXJ_AROAE;  
A1K607, PDXJ_AZOSB;  C1DQS7, PDXJ_AZOVD;  Q5L912, PDXJ_BACFN;  
Q3V814, PDXJ_BACFR;  Q8A0V3, PDXJ_BACTN;  A6KXM3, PDXJ_BACV8;  
Q3V7R4, PDXJ_BDEBA;  Q7VRR1, PDXJ_BLOFL;  Q492D2, PDXJ_BLOPB;  
Q2KXM4, PDXJ_BORA1;  Q7WH63, PDXJ_BORBR;  Q7W9J7, PDXJ_BORPA;  
A9IUY4, PDXJ_BORPD;  Q7VWW0, PDXJ_BORPE;  O69158, PDXJ_BRADU;  
A4YWD1, PDXJ_BRASO;  B2S6L0, PDXJ_BRUA1;  Q2YQM7, PDXJ_BRUA2;  
Q57CC2, PDXJ_BRUAB;  A9M642, PDXJ_BRUC2;  C0RE25, PDXJ_BRUMB;  
Q8YI24, PDXJ_BRUME;  A5VRD3, PDXJ_BRUO2;  B0CHH2, PDXJ_BRUSI;  
Q8FZT6, PDXJ_BRUSU;  Q39I70, PDXJ_BURL3;  Q3V7M2, PDXJ_BURMA;  
Q3JQ80, PDXJ_BURP1;  Q3V7S9, PDXJ_BURPS;  A0RNS2, PDXJ_CAMFF;  
A7I3Y5, PDXJ_CAMHC;  A8FMU3, PDXJ_CAMJ8;  A7H2E1, PDXJ_CAMJD;  
Q9PN59, PDXJ_CAMJE;  A1W0M1, PDXJ_CAMJJ;  Q5HTM5, PDXJ_CAMJR;  
B9KCG6, PDXJ_CAMLR;  B8H623, PDXJ_CAUCN;  Q9A808, PDXJ_CAUCR;  
B0T3H6, PDXJ_CAUSK;  Q11I86, PDXJ_CHESB;  Q3ATB8, PDXJ_CHLCH;  
B3QQ93, PDXJ_CHLP8;  B3ELU3, PDXJ_CHLPB;  A1BE95, PDXJ_CHLPD;  
B3QTV1, PDXJ_CHLT3;  Q8KFJ5, PDXJ_CHLTE;  Q7NWC0, PDXJ_CHRVO;  
Q47WP8, PDXJ_COLP3;  A9KFA7, PDXJ_COXBN;  A9N936, PDXJ_COXBR;  
Q83BL1, PDXJ_COXBU;  Q0K8N6, PDXJ_CUPNH;  Q46Z21, PDXJ_CUPPJ;  
B3R1Z6, PDXJ_CUPTR;  B1WY64, PDXJ_CYAA5;  B8HKL1, PDXJ_CYAP4;  
B7K7E4, PDXJ_CYAP7;  Q11PM4, PDXJ_CYTH3;  Q47EF4, PDXJ_DECAR;  
B8FJ89, PDXJ_DESAA;  C6BV77, PDXJ_DESAD;  Q30ZQ6, PDXJ_DESAG;  
C0Q9S7, PDXJ_DESAH;  C4XGU0, PDXJ_DESMR;  A8ZVC5, PDXJ_DESOH;  
Q3V891, PDXJ_DESVH;  B8DPF1, PDXJ_DESVM;  A1VCV9, PDXJ_DESVV;  
P0A795, PDXJ_ECO57;  Q8FF18, PDXJ_ECOL6;  P0A794, PDXJ_ECOLI;  
Q3YSI5, PDXJ_EHRCJ;  Q2GG30, PDXJ_EHRCR;  Q5FHH4, PDXJ_EHRRG;  
Q5HBN7, PDXJ_EHRRW;  B2KEC4, PDXJ_ELUMP;  A5FJ95, PDXJ_FLAJ1;  
B5EHA6, PDXJ_GEOBB;  B9M5K2, PDXJ_GEODF;  B3E693, PDXJ_GEOLS;  
Q39UG0, PDXJ_GEOMG;  Q3V8C9, PDXJ_GEOSL;  C6E5P6, PDXJ_GEOSM;  
A5G535, PDXJ_GEOUR;  Q7NPF2, PDXJ_GLOVI;  Q5FNS2, PDXJ_GLUOX;  
A0LXW0, PDXJ_GRAFK;  Q17ZN1, PDXJ_HELAH;  Q7VHV1, PDXJ_HELHP;  
B6JP91, PDXJ_HELP2;  B5Z9L2, PDXJ_HELPG;  Q1CR25, PDXJ_HELPH;  
Q9ZJ29, PDXJ_HELPJ;  B2UVZ8, PDXJ_HELPS;  O26102, PDXJ_HELPY;  
B4U872, PDXJ_HYDS0;  Q5R109, PDXJ_IDILO;  Q28V29, PDXJ_JANSC;  
C1D7L7, PDXJ_LARHH;  Q3V7G1, PDXJ_LEGPA;  A5IFW5, PDXJ_LEGPC;  
Q3V870, PDXJ_LEGPH;  Q3V7F6, PDXJ_LEGPL;  B0SBH6, PDXJ_LEPBA;  
B0SJ25, PDXJ_LEPBP;  A0L8S5, PDXJ_MAGSM;  Q3V8A2, PDXJ_METCA;  
B3DF93, PDXJ_MICAN;  B9LAE4, PDXJ_NAUPA;  Q5F6P1, PDXJ_NEIG1;  
A9M276, PDXJ_NEIM0;  Q9RQV9, PDXJ_NEIMA;  Q9K0V9, PDXJ_NEIMB;  
Q9RML6, PDXJ_NEIMC;  A1KVH8, PDXJ_NEIMF;  Q0AF72, PDXJ_NITEC;  
Q82SJ7, PDXJ_NITEU;  Q2Y865, PDXJ_NITMU;  Q3JCY8, PDXJ_NITOC;  
A6Q3Y6, PDXJ_NITSB;  Q3SRB0, PDXJ_NITWN;  B2J448, PDXJ_NOSP7;  
Q8Z080, PDXJ_NOSS1;  A6WZX2, PDXJ_OCHA4;  B1ZNA6, PDXJ_OPITP;  
A6LC86, PDXJ_PARD8;  Q3V7N3, PDXJ_PECAS;  Q3A5V4, PDXJ_PELCD;  
Q3B5P7, PDXJ_PELLD;  B4SDS5, PDXJ_PELPB;  A1AR94, PDXJ_PELPD;  
Q4FLS6, PDXJ_PELUB;  C0QU74, PDXJ_PERMH;  Q7N1X8, PDXJ_PHOLL;  
Q3V7I6, PDXJ_PHOPR;  B2RIJ5, PDXJ_PORG3;  Q51843, PDXJ_PORGI;  
B4S3G9, PDXJ_PROA2;  A2C3H1, PDXJ_PROM1;  A8G5H7, PDXJ_PROM2;  
A2C897, PDXJ_PROM3;  A9BAZ9, PDXJ_PROM4;  A2BX94, PDXJ_PROM5;  
Q31AB8, PDXJ_PROM9;  Q7VBK3, PDXJ_PROMA;  Q7V6Q5, PDXJ_PROMM;  
Q7V0Y7, PDXJ_PROMP;  A2BRT6, PDXJ_PROMS;  Q46K45, PDXJ_PROMT;  
A4SDF7, PDXJ_PROVI;  Q48EV6, PDXJ_PSE14;  A6VAK3, PDXJ_PSEA7;  
B7UYW9, PDXJ_PSEA8;  Q02HS5, PDXJ_PSEAB;  Q9I5G5, PDXJ_PSEAE;  
Q1I5W1, PDXJ_PSEE4;  Q4KHS8, PDXJ_PSEF5;  C3K6Z0, PDXJ_PSEFS;  
Q3IDK9, PDXJ_PSEHT;  A4XSC7, PDXJ_PSEMY;  A5W8E9, PDXJ_PSEP1;  
Q3KHL6, PDXJ_PSEPF;  B0KV24, PDXJ_PSEPG;  Q88MY2, PDXJ_PSEPK;  
B1J4E3, PDXJ_PSEPW;  Q87XG4, PDXJ_PSESM;  Q4ZPE4, PDXJ_PSEU2;  
A4VIX8, PDXJ_PSEU5;  Q4FUV3, PDXJ_PSYA2;  Q1QDV0, PDXJ_PSYCK;  
Q1LKN4, PDXJ_RALME;  B2U984, PDXJ_RALPJ;  Q8Y0H8, PDXJ_RALSO;  
Q98KL6, PDXJ_RHILO;  Q92NT6, PDXJ_RHIME;  Q7UYK5, PDXJ_RHOBA;  
Q21XM2, PDXJ_RHOFT;  Q2IWU8, PDXJ_RHOP2;  Q3V7S0, PDXJ_RHOPA;  
Q214J9, PDXJ_RHOPB;  Q136W2, PDXJ_RHOPS;  B3QJH1, PDXJ_RHOPT;  
Q2RT91, PDXJ_RHORT;  A3PGF5, PDXJ_RHOS1;  Q3J5W4, PDXJ_RHOS4;  
Q16AJ0, PDXJ_ROSDO;  Q3V7J3, PDXJ_RUEPO;  Q57LD3, PDXJ_SALCH;  
Q3V7K1, PDXJ_SALPA;  Q2S0U5, PDXJ_SALRD;  Q8Z4K6, PDXJ_SALTI;  
Q8ZN19, PDXJ_SALTY;  Q8EH78, PDXJ_SHEON;  Q31XS3, PDXJ_SHIBS;  
Q32CV7, PDXJ_SHIDS;  Q3YYV2, PDXJ_SHISS;  Q30S57, PDXJ_SULDN;  
A6QAX8, PDXJ_SULNB;  B2V6U1, PDXJ_SULSY;  Q8KPR0, PDXJ_SYNE7;  
A0LK96, PDXJ_SYNFM;  Q2JSG7, PDXJ_SYNJA;  Q2JP46, PDXJ_SYNJB;  
Q3V812, PDXJ_SYNP6;  A5GLI2, PDXJ_SYNPW;  Q7U7S1, PDXJ_SYNPX;  
A5GU97, PDXJ_SYNR3;  Q0IB11, PDXJ_SYNS3;  Q3AVH3, PDXJ_SYNS9;  
Q3AJ26, PDXJ_SYNSC;  P72776, PDXJ_SYNY3;  Q8DKM1, PDXJ_THEEB;  
B5YGR4, PDXJ_THEYD;  Q31HP0, PDXJ_THICR;  Q3SH53, PDXJ_THIDA;  
B8GPL4, PDXJ_THISH;  Q10X41, PDXJ_TRIEI;  Q9KPB5, PDXJ_VIBCH;  
Q5E317, PDXJ_VIBF1;  Q87LP2, PDXJ_VIBPA;  Q8DC73, PDXJ_VIBVU;  
Q7MHP1, PDXJ_VIBVY;  Q8D304, PDXJ_WIGBR;  Q3V8B3, PDXJ_WOLPM;  
B3CLF3, PDXJ_WOLPP;  Q7MAP8, PDXJ_WOLSU;  C0R576, PDXJ_WOLWR;  
Q8PRF1, PDXJ_XANAC;  Q3BZR9, PDXJ_XANC5;  Q4V0R7, PDXJ_XANC8;  
B0RLF1, PDXJ_XANCB;  Q8PEG8, PDXJ_XANCP;  Q2P9L0, PDXJ_XANOM;  
B2SUX4, PDXJ_XANOP;  Q5H704, PDXJ_XANOR;  A7IM59, PDXJ_XANP2;  
B2I669, PDXJ_XYLF2;  Q9PH84, PDXJ_XYLFA;  B0U2A9, PDXJ_XYLFM;  
Q87F88, PDXJ_XYLFT;  Q8ZCP4, PDXJ_YERPE;  Q3V7P0, PDXJ_YERPS;  
Q5NLS8, PDXJ_ZYMMO;  

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