ENZYME entry: EC 22.214.171.124
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|Glycine cleavage system.
|Glycine + tetrahydrofolate + NAD(+) <=> 5,10-methylenetetrahydrofolate + NH(3) + CO(2) + NADH|
- The glycine cleavage (GCV) system is a large multienzyme complex that
belongs to the 2-oxoacid dehydrogenase complex family, which also
includes EC 126.96.36.199, EC 188.8.131.52, EC 184.108.40.206 and EC 220.127.116.11.
- The GCV system catalyzes the reversible oxidation of glycine,
yielding carbon dioxide, ammonia, 5,10-methylenetetrahydrofolate and
a reduced pyridine nucleotide.
- Tetrahydrofolate serves as a recipient for one-carbon units generated
during glycine cleavage to form the methylene group.
- The GCV system consists of four protein components, the P protein
(EC 18.104.22.168), T protein (EC 22.214.171.124), L protein (EC 126.96.36.199),
and the non-enzyme H protein (lipoyl-carrier protein).
- The P protein catalyzes the pyridoxal phosphate-dependent liberation
of CO(2) from glycine, leaving a methylamine moiety.
- The methylamine moiety is transferred to the lipoic acid group of the
H protein, which is bound to the P protein prior to decarboxylation
- The T protein catalyzes the release of ammonia from the methylamine
group and transfers the remaining C(1) unit to tetrahydrofolate,
- The L protein then oxidizes the lipoic acid component of the H
protein and transfers the electrons to NAD(+), forming NADH.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
|Rhea expert-curated reactions||22.214.171.124|
entries corresponding to 1.4.1.-
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