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ENZYME entry: EC 2.1.1.133

Accepted Name
Precorrin-4 C(11)-methyltransferase.
Alternative Name(s)
Precorrin-3 methylase.
Precorrin-4 C11-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + precorrin-4 <=> S-adenosyl-L-homocysteine + precorrin-5
Comment(s)
  • In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A.
  • The first of the four steps is carried out by EC 1.14.13.83 (CobG), yielding precorrin-3B as the product.
  • This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5, and precorrin-6A, respectively.
  • See EC 2.1.1.271 for the C(11)-methyltransferase enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
Cross-references
BRENDA2.1.1.133
EC2PDB2.1.1.133
ExplorEnz2.1.1.133
PRIAM enzyme-specific profiles2.1.1.133
KEGG Ligand Database for Enzyme Nomenclature2.1.1.133
IUBMB Enzyme Nomenclature2.1.1.133
IntEnz2.1.1.133
MEDLINEFind literature relating to 2.1.1.133
MetaCyc2.1.1.133
Rhea expert-curated reactions2.1.1.133
UniProtKB/Swiss-Prot
P9WGB0, COBM_MYCTO;  P9WGB1, COBM_MYCTU;  Q9HZP9, COBM_PSEAE;  
O68100, COBM_RHOCB;  Q53138, COBM_RHOER;  P21922, COBM_SINSX;  

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