Home  |  Contact

ENZYME entry: EC

Accepted Name
Precorrin-4 C(11)-methyltransferase.
Alternative Name(s)
Precorrin-3 methylase.
Precorrin-4 C11-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + precorrin-4 <=> S-adenosyl-L-homocysteine + precorrin-5
  • In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A.
  • The first of the four steps is carried out by EC (CobG), yielding precorrin-3B as the product.
  • This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC, C-11 (CobM; EC and C-1 (CobF; EC of the macrocycle, giving rise to precorrin-4, precorrin-5, and precorrin-6A, respectively.
  • See EC for the C(11)-methyltransferase enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
PRIAM enzyme-specific profiles2.1.1.133
KEGG Ligand Database for Enzyme Nomenclature2.1.1.133
IUBMB Enzyme Nomenclature2.1.1.133
MEDLINEFind literature relating to
Rhea expert-curated reactions2.1.1.133
O68100, COBM_RHOCB;  Q53138, COBM_RHOER;  P21922, COBM_SINSX;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-