ENZYME entry: EC 2.1.1.133
Accepted Name |
Precorrin-4 C(11)-methyltransferase.
|
Alternative Name(s) |
Precorrin-3 methylase. |
Precorrin-4 C11-methyltransferase. |
Reaction catalysed |
S-adenosyl-L-methionine + precorrin-4 <=> S-adenosyl-L-homocysteine + precorrin-5 |
Comment(s) |
- In the aerobic cobalamin biosythesis pathway, four enzymes are
involved in the conversion of precorrin-3A to precorrin-6A.
- The first of the four steps is carried out by EC 1.14.13.83 (CobG),
yielding precorrin-3B as the product.
- This is followed by three methylation reactions, which introduce a
methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; 2.1.1.133) and
C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-
4, precorrin-5 and precorrin-6A, respectively.
|
Cross-references |
BRENDA | 2.1.1.133 |
EC2PDB | 2.1.1.133 |
ExplorEnz | 2.1.1.133 |
PRIAM enzyme-specific profiles | 2.1.1.133 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.133 |
IUBMB Enzyme Nomenclature | 2.1.1.133 |
IntEnz | 2.1.1.133 |
MEDLINE | Find literature relating to 2.1.1.133 |
MetaCyc | 2.1.1.133 |
UniProtKB/Swiss-Prot |
|
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