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ENZYME

ENZYME entry: EC 3.3.2.11

Accepted Name
cholesterol-5,6-oxide hydrolase
Alternative Name(s)
ChEH
cholesterol-epoxide hydrolase
Reaction catalysed
  • 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol
  • 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol
Comment(s)
  • The enzyme appears to work equally well with both diastereoisomers of cholesterol 5,6-epoxide.
  • The product is a competitive inhibitor of the reaction.
Cross-references
BRENDA3.3.2.11
EC2PDB3.3.2.11
ExplorEnz3.3.2.11
PRIAM enzyme-specific profiles3.3.2.11
KEGG Ligand Database for Enzyme Nomenclature3.3.2.11
IUBMB Enzyme Nomenclature3.3.2.11
IntEnz3.3.2.11
MEDLINEFind literature relating to 3.3.2.11
MetaCyc3.3.2.11
Rhea expert-curated reactions3.3.2.11
UniProtKB/Swiss-Prot
O33283, EPHG_MYCTU

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