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ENZYME

ENZYME entry: EC 4.1.1.48

Accepted Name
indole-3-glycerol-phosphate synthase
Alternative Name(s)
indoleglycerol phosphate synthetase
Reaction catalysed
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
Comment(s)
In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).
Cross-references
BRENDA4.1.1.48
EC2PDB4.1.1.48
ExplorEnz4.1.1.48
PRIAM enzyme-specific profiles4.1.1.48
KEGG Ligand Database for Enzyme Nomenclature4.1.1.48
IUBMB Enzyme Nomenclature4.1.1.48
IntEnz4.1.1.48
MEDLINEFind literature relating to 4.1.1.48
MetaCyc4.1.1.48
Rhea expert-curated reactions4.1.1.48
UniProtKB/Swiss-Prot
Q8XVE6, TRPC1_RALN1O68814, TRPC1_STRCOQ8XS01, TRPC2_RALN1
Q9Z4X0, TRPC2_STRCOO28668, TRPCD_ARCFUB0CEU2, TRPC_ACAM1
A3DDS7, TRPC_ACET2P00911, TRPC_ACIADB7I441, TRPC_ACIB5
B2HVE7, TRPC_ACIBCB0VUS0, TRPC_ACIBSA3M785, TRPC_ACIBT
B0VBS1, TRPC_ACIBYB9MBS5, TRPC_ACIETB7JBC0, TRPC_ACIF2
B5ERI2, TRPC_ACIF5A1W2Z8, TRPC_ACISJQ9Y8T7, TRPC_AERPE
B6JG29, TRPC_AFIC5Q7CYR2, TRPC_AGRFCQ21SE8, TRPC_ALBFT
A8ET36, TRPC_ALIB4A6TM74, TRPC_ALKMQB9JX64, TRPC_ALLAM
O67657, TRPC_AQUAEP49572, TRPC_ARATHQ5P2G1, TRPC_AROAE
A0JVL1, TRPC_ARTS2P26938, TRPC_AZOBRA8I836, TRPC_AZOC5
A1KAT2, TRPC_AZOSBC1DHY7, TRPC_AZOVDC3P3T8, TRPC_BACAA
C3LAW0, TRPC_BACACA0RB62, TRPC_BACAHQ81TM0, TRPC_BACAN
B7JES8, TRPC_BACC0Q73BQ9, TRPC_BACC1B7IM74, TRPC_BACC2
C1ELE8, TRPC_BACC3B7HGZ9, TRPC_BACC4B7I0F0, TRPC_BACC7
B9IU36, TRPC_BACCQQ81GG7, TRPC_BACCRQ63EC9, TRPC_BACCZ
Q6HLU6, TRPC_BACHKQ65I33, TRPC_BACLDA9VJW0, TRPC_BACMK
A8FEK0, TRPC_BACP2P18268, TRPC_BACPUP03964, TRPC_BACSU
Q8AAD6, TRPC_BACTNA7Z618, TRPC_BACVZB2IKL7, TRPC_BEII9
C5BV85, TRPC_BEUC1Q2KU99, TRPC_BORA1Q7WEK6, TRPC_BORBR
Q7W387, TRPC_BORPAA9HY11, TRPC_BORPDQ7VU67, TRPC_BORPE
P94327, TRPC_BRADUA5EK25, TRPC_BRASBA4YVD6, TRPC_BRASO
B2S5Z1, TRPC_BRUA1Q2YRR4, TRPC_BRUA2A6X0L0, TRPC_BRUA4
Q57CZ8, TRPC_BRUABA9M5F4, TRPC_BRUC2C0RJB1, TRPC_BRUMB
P66988, TRPC_BRUMEA5VQR5, TRPC_BRUO2B0CGT9, TRPC_BRUSI
P66989, TRPC_BRUSUP57366, TRPC_BUCAIP42393, TRPC_BUCAP
P59459, TRPC_BUCBPO68427, TRPC_BUCDNQ44603, TRPC_BUCSC
B1YSF5, TRPC_BURA4A0K458, TRPC_BURCHQ0BIM8, TRPC_BURCM
Q39JZ7, TRPC_BURL3A9AJ43, TRPC_BURM1A3MFQ4, TRPC_BURM7
A2RYI3, TRPC_BURM9Q62DD0, TRPC_BURMAA1UWA0, TRPC_BURMS
B1JUU5, TRPC_BURO0Q1BSD2, TRPC_BURO1A3NZP6, TRPC_BURP0
Q3JNB0, TRPC_BURP1A3NDZ3, TRPC_BURP6Q63QH0, TRPC_BURPS
Q2SUI0, TRPC_BURTAA4JB67, TRPC_BURVGQ8R9M7, TRPC_CALS4
A8Z6K1, TRPC_CAMC1A7GYQ7, TRPC_CAMC5A0RNN3, TRPC_CAMFF
A7I2Y2, TRPC_CAMHCA8FKS2, TRPC_CAMJ8A7H4P0, TRPC_CAMJD
Q9PI11, TRPC_CAMJEA1VYK3, TRPC_CAMJJQ5HVR3, TRPC_CAMJR
Q3ABS1, TRPC_CARHZB0SYZ4, TRPC_CAUSKQ9A727, TRPC_CAUVC
B8GWP9, TRPC_CAUVNA3PHK7, TRPC_CERS1Q9ZFA7, TRPC_CERS4
A4WX67, TRPC_CERS5B9KMV0, TRPC_CERSKQ11HU1, TRPC_CHESB
Q3AU73, TRPC_CHLCHB3EG28, TRPC_CHLL2Q3B2C7, TRPC_CHLL3
B3QLY7, TRPC_CHLP8A1BDW1, TRPC_CHLPDA4SG41, TRPC_CHLPM
B3QZD6, TRPC_CHLT3Q8KBW1, TRPC_CHLTEQ7NUI6, TRPC_CHRVO
Q97EF3, TRPC_CLOABB9E149, TRPC_CLOK1A5N7N8, TRPC_CLOK5
P06560, TRPC_CORGLB1WQE4, TRPC_CROS5Q0K6I0, TRPC_CUPNH
Q46WU7, TRPC_CUPPJB3R703, TRPC_CUPTRB8HP79, TRPC_CYAP4
Q47AC7, TRPC_DECARQ3Z6G5, TRPC_DEHM1A5FPM3, TRPC_DEHMB
Q3ZZ14, TRPC_DEHMCQ9RUG0, TRPC_DEIRAA9BS06, TRPC_DELAS
A8ZZX0, TRPC_DESOHQ6AMS4, TRPC_DESPSA4J147, TRPC_DESRM
A5EVG3, TRPC_DICNVQ8X7B7, TRPC_ECO57P00909, TRPC_ECOLI
B1GZC0, TRPC_ENDTXB1YLS2, TRPC_EXIS2C4KZ66, TRPC_EXISA
Q0RFX9, TRPC_FRAAAA8LGR8, TRPC_FRASNQ5KXU9, TRPC_GEOKA
C5D3D6, TRPC_GEOSWA4IQ84, TRPC_GEOTNQ7NHI0, TRPC_GLOVI
P46451, TRPC_HAEINQ9KCB2, TRPC_HALH5Q5V138, TRPC_HALMA
Q9HSC1, TRPC_HALSAP18304, TRPC_HALVDQ9ZJU8, TRPC_HELPJ
O25867, TRPC_HELPYA4G1P4, TRPC_HERARQ0C1A2, TRPC_HYPNA
A6SUH5, TRPC_JANMAA6WC91, TRPC_KINRDQ1ISJ1, TRPC_KORVE
P17217, TRPC_LACCAB3W6W8, TRPC_LACCBC4Z138, TRPC_LACE2
Q01999, TRPC_LACLAA2RK21, TRPC_LACLMQ02YB4, TRPC_LACLS
Q03CY1, TRPC_LACP3A9KL43, TRPC_LACP7Q88WI2, TRPC_LACPL
C1D7J7, TRPC_LARHHQ5X6S0, TRPC_LEGPAA5IG82, TRPC_LEGPC
Q5ZX99, TRPC_LEGPHQ5WY75, TRPC_LEGPLQ6AF68, TRPC_LEIXX
B1Y7I2, TRPC_LEPCPQ72NP6, TRPC_LEPICQ8F7V2, TRPC_LEPIN
Q03X00, TRPC_LEUMMQ92B79, TRPC_LISINC1KVS7, TRPC_LISMC
Q71Z38, TRPC_LISMFB8DHB2, TRPC_LISMHQ8Y6Q4, TRPC_LISMO
A0AJ82, TRPC_LISW6A0LA39, TRPC_MAGMMQ58328, TRPC_METJA
Q8TVJ8, TRPC_METKAA4YHD8, TRPC_METS5B8EJS1, TRPC_METSB
O27694, TRPC_METTHP26939, TRPC_METTMB0JTM2, TRPC_MICAN
C5CBK6, TRPC_MICLCA0QHH0, TRPC_MYCA1B1MBV4, TRPC_MYCA9
P0A633, TRPC_MYCBOA1KJ27, TRPC_MYCBPC1ANN3, TRPC_MYCBT
A4T9N5, TRPC_MYCGIB8ZRB9, TRPC_MYCLBQ9X7C7, TRPC_MYCLE
B2HQX7, TRPC_MYCMMQ740P4, TRPC_MYCPAA0QX95, TRPC_MYCS2
A3Q119, TRPC_MYCSJA1UHJ6, TRPC_MYCSKQ1B7H6, TRPC_MYCSS
A5U2W7, TRPC_MYCTAP9WFX6, TRPC_MYCTOP9WFX7, TRPC_MYCTU
A0PP28, TRPC_MYCUAA1T8X3, TRPC_MYCVPB9LAF4, TRPC_NAUPA
Q5F645, TRPC_NEIG1B4RPF1, TRPC_NEIG2Q9JSN4, TRPC_NEIMA
Q9K192, TRPC_NEIMBA1KRV4, TRPC_NEIMFQ1QMJ9, TRPC_NITHX
A6Q3P0, TRPC_NITSBQ3SRJ3, TRPC_NITWNA1SL44, TRPC_NOCSJ
Q2G6R0, TRPC_NOVADQ8ESU2, TRPC_OCEIHB1ZW79, TRPC_OPITP
A1R5S7, TRPC_PAEATA1TJQ2, TRPC_PARC0A7HXZ6, TRPC_PARL1
Q7TTU3, TRPC_PARMWB2JHI8, TRPC_PARP8B2SZ04, TRPC_PARPJ
Q13TW4, TRPC_PARXLP57855, TRPC_PASMUB4SDV8, TRPC_PELPB
A9BHQ5, TRPC_PETMOB4RBX5, TRPC_PHEZHP24920, TRPC_PHYNI
Q6L277, TRPC_PICTOA4SV52, TRPC_POLAQA1VTG7, TRPC_POLNA
B1XSZ1, TRPC_POLNSQ123F4, TRPC_POLSJP70937, TRPC_PRIM1
A3PED0, TRPC_PROM0A2C462, TRPC_PROM1A8G6A7, TRPC_PROM2
A2CB59, TRPC_PROM3A9BBR3, TRPC_PROM4A2BY04, TRPC_PROM5
Q319J2, TRPC_PROM9Q7VAT3, TRPC_PROMAQ7TV44, TRPC_PROMM
Q7TU64, TRPC_PROMPA2BSL8, TRPC_PROMSQ46JH4, TRPC_PROMT
Q48NP7, TRPC_PSE14A6UZF2, TRPC_PSEA7B7V609, TRPC_PSEA8
Q02TB5, TRPC_PSEABP20577, TRPC_PSEAEQ1IFZ9, TRPC_PSEE4
Q4K503, TRPC_PSEF5C3K307, TRPC_PSEFSA4XZC5, TRPC_PSEMY
A5VXL5, TRPC_PSEP1Q3K5V4, TRPC_PSEPFB0KK35, TRPC_PSEPG
Q88QR6, TRPC_PSEPKP20578, TRPC_PSEPUB1JE34, TRPC_PSEPW
Q88A03, TRPC_PSESMQ9V1G3, TRPC_PYRABQ8ZYX2, TRPC_PYRAE
A4WN19, TRPC_PYRARQ8U088, TRPC_PYRFUB1YBK5, TRPC_PYRNV
B2UDK9, TRPC_RALPJB3Q0L3, TRPC_RHIE6Q2K879, TRPC_RHIEC
Q1MGE1, TRPC_RHIJ3Q98ME3, TRPC_RHILOB5ZPY7, TRPC_RHILW
Q92PR9, TRPC_RHIMEB9JFD8, TRPC_RHIR8A5VBA0, TRPC_RHIWR
Q7UKJ7, TRPC_RHOBAQ02584, TRPC_RHOCBQ0SHZ5, TRPC_RHOJR
C1AT55, TRPC_RHOOBQ2IWB0, TRPC_RHOP2Q07NF6, TRPC_RHOP5
Q215B9, TRPC_RHOPBQ136D2, TRPC_RHOPSB3Q6M9, TRPC_RHOPT
Q2RT48, TRPC_RHORTB7K0H0, TRPC_RIPO1A7NMZ8, TRPC_ROSCS
A5USQ4, TRPC_ROSS1B8I0V0, TRPC_RUMCHA4FLL0, TRPC_SACEN
Q06121, TRPC_SACS2Q2S1Z5, TRPC_SALRDQ8Z7D9, TRPC_SALTI
P00910, TRPC_SALTYQ5WGS3, TRPC_SHOC1C3MCF2, TRPC_SINFN
A6U9C5, TRPC_SINMWA7X234, TRPC_STAA1A6U1J2, TRPC_STAA2
Q2FH66, TRPC_STAA3Q2FYR6, TRPC_STAA8A5ISQ2, TRPC_STAA9
Q2YXU9, TRPC_STAABQ9RL78, TRPC_STAACA6QGS2, TRPC_STAAE
P66990, TRPC_STAAMP66991, TRPC_STAANQ6GH35, TRPC_STAAR
Q6G9I9, TRPC_STAASA8Z242, TRPC_STAATQ8NWU3, TRPC_STAAW
Q5HPH2, TRPC_STAEQQ8CPB2, TRPC_STAESQ4L677, TRPC_STAHJ
Q49XH6, TRPC_STAS1Q82A84, TRPC_STRAWA8AW03, TRPC_STRGC
B1W0N8, TRPC_STRGGB4SLE8, TRPC_STRM5B2FKL1, TRPC_STRMK
Q8DVF5, TRPC_STRMUQ04IY7, TRPC_STRP2B5E7M5, TRPC_STRP4
C1C968, TRPC_STRP7B1I7S9, TRPC_STRPIB8ZN61, TRPC_STRPJ
Q97P30, TRPC_STRPNB2ISS3, TRPC_STRPSQ8DNM6, TRPC_STRR6
A3CLL9, TRPC_STRSVQ5LYI5, TRPC_STRT1Q5M348, TRPC_STRT2
Q03JB9, TRPC_STRTDC1CG44, TRPC_STRZJC1CMD5, TRPC_STRZP
C1CT53, TRPC_STRZTA4VHK1, TRPC_STUS1Q4J8X3, TRPC_SULAC
Q30SM1, TRPC_SULDNQ972A1, TRPC_SULTOQ8KPR4, TRPC_SYNE7
A0LJ58, TRPC_SYNFMQ5N575, TRPC_SYNP6A5GMK4, TRPC_SYNPW
A5GRL0, TRPC_SYNR3Q0IC57, TRPC_SYNS3Q3AV87, TRPC_SYNS9
Q3AL94, TRPC_SYNSCQ55508, TRPC_SYNY3Q9HK02, TRPC_THEAC
Q47QR5, TRPC_THEFYQ9YGB5, TRPC_THEKOQ56319, TRPC_THEMA
B0K8T4, TRPC_THEP3B0K2U1, TRPC_THEPXQ979V9, TRPC_THEVO
Q3SGS2, TRPC_THIDAQ10ZM7, TRPC_TRIEIC5CKE4, TRPC_VARPS
A1WH73, TRPC_VEREIQ9KST5, TRPC_VIBCHP22098, TRPC_VIBPA
Q7M831, TRPC_WOLSUQ8PQ47, TRPC_XANACQ4UZF8, TRPC_XANC8
Q8PD70, TRPC_XANCPQ3BYB5, TRPC_XANE5Q2NYD7, TRPC_XANOM
B2SL03, TRPC_XANOPA7INK2, TRPC_XANP2B2I6S5, TRPC_XYLF2
Q9PGT5, TRPC_XYLFAB0U1P0, TRPC_XYLFMQ87EX2, TRPC_XYLFT
Q8ZEG8, TRPC_YERPEQ5NQ36, TRPC_ZYMMOQ9XBM3, TRPC_ZYMMT
P18483, TRPG_ASPAWP05328, TRPG_ASPNGQ92411, TRPG_COCHE
P0CN87, TRPG_CRYNBP27710, TRPG_CRYNHP0CN86, TRPG_CRYNJ
P06531, TRPG_EMENIP00908, TRPG_NEUCRP24773, TRPG_PENCH
P25170, TRPG_PHACHP20409, TRPG_PHYBLP09575, TRPG_PICAN
Q92370, TRPG_SCHPOP00937, TRPG_YEAST

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-