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ENZYME entry: EC 4.1.3.27

Accepted Name
anthranilate synthase.
Reaction catalysed
chorismate + L-glutamine <=> anthranilate + H(+) + L-glutamate + pyruvate
Comment(s)
  • The enzyme, found in plants, fungi and bacteria is composed of two parts, a glutaminase subunit and a lyase subunit.
  • The glutaminase produces ammonia that is channeled to the lyase subunit.
  • In the absence of the glutaminase, the lyase can convert ammonia and chorismate into anthranilate.
  • In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.2.1.20, and EC 5.3.1.24).
Cross-references
BRENDA4.1.3.27
EC2PDB4.1.3.27
ExplorEnz4.1.3.27
PRIAM enzyme-specific profiles4.1.3.27
KEGG Ligand Database for Enzyme Nomenclature4.1.3.27
IUBMB Enzyme Nomenclature4.1.3.27
IntEnz4.1.3.27
MEDLINEFind literature relating to 4.1.3.27
MetaCyc4.1.3.27
Rhea expert-curated reactions4.1.3.27
UniProtKB/Swiss-Prot
A2XNK3, ASA1_ORYSI;  Q94GF1, ASA1_ORYSJ;  Q9XJ29, ASA2_ORYSJ;  
Q42565, ASB1_ARATH;  Q7XUS2, ASB1_ORYSJ;  Q9FJM5, ASB2_ARATH;  
Q764B9, ASB2_ORYSJ;  P28819, PABA_BACSU;  P09785, PHNA_PSEAE;  
P09786, PHNB_PSEAE;  Q51519, PHZB_PSECL;  Q51791, PHZE_PSEFL;  
P74130, TRE2_SYNY3;  Q5V448, TRPE1_HALMA;  Q9HPG5, TRPE1_HALSA;  
Q5V213, TRPE2_HALMA;  Q9HS66, TRPE2_HALSA;  Q5V631, TRPE3_HALMA;  
P14953, TRPE_ACETH;  P23315, TRPE_ACICA;  Q9Y8T0, TRPE_AERPE;  
O66849, TRPE_AQUAE;  P32068, TRPE_ARATH;  O28669, TRPE_ARCFU;  
P96556, TRPE_ARTGO;  P50872, TRPE_AZOBR;  P30526, TRPE_BACCA;  
P18267, TRPE_BACPU;  P03963, TRPE_BACSU;  Q44695, TRPE_BUCAI;  
P42387, TRPE_BUCAP;  Q89A29, TRPE_BUCBP;  Q44697, TRPE_BUCDN;  
Q9ZER9, TRPE_BUCPS;  Q44689, TRPE_BUCRM;  Q44691, TRPE_BUCRP;  
Q44598, TRPE_BUCSC;  Q9ZES2, TRPE_BUCTC;  P95646, TRPE_CERS4;  
P00896, TRPE_CITFR;  P06557, TRPE_CORGL;  P00895, TRPE_ECOLI;  
Q9X6J4, TRPE_GEOSE;  P43761, TRPE_HAEIN;  P33975, TRPE_HALVD;  
Q9ZJU5, TRPE_HELPJ;  O25869, TRPE_HELPY;  Q02001, TRPE_LACLA;  
P20463, TRPE_LEPBI;  Q58475, TRPE_METJA;  O27692, TRPE_METTH;  
P26940, TRPE_METTM;  P67002, TRPE_MYCBO;  Q9X7C5, TRPE_MYCLE;  
A0QX93, TRPE_MYCS2;  P9WFX2, TRPE_MYCTO;  P9WFX3, TRPE_MYCTU;  
Q5F8B4, TRPE_NEIG1;  Q9WW00, TRPE_NEIGO;  Q9XAZ0, TRPE_NEIMA;  
P56995, TRPE_NEIMB;  Q9S358, TRPE_NEIMF;  P20580, TRPE_PSEAE;  
P20579, TRPE_PSEPU;  P21689, TRPE_PSESS;  P15395, TRPE_RHIME;  
Q06128, TRPE_SACS2;  P00898, TRPE_SALTY;  O94582, TRPE_SCHPO;  
P00897, TRPE_SERMA;  P21690, TRPE_SPIAU;  Q9Z4W7, TRPE_STRCO;  
P20170, TRPE_SYNY3;  Q9YGB3, TRPE_THEKO;  Q08653, TRPE_THEMA;  
P05378, TRPE_THET8;  Q9KST2, TRPE_VIBCH;  P22099, TRPE_VIBPA;  
P00899, TRPE_YEAST;  Q5V214, TRPG1_HALMA;  Q5V632, TRPG2_HALMA;  
P00904, TRPGD_ECOLI;  P00905, TRPGD_SALTY;  Q08654, TRPGD_THEMA;  
P14952, TRPG_ACETH;  P00902, TRPG_ACIAD;  O28670, TRPG_ARCFU;  
P18483, TRPG_ASPAW;  P05328, TRPG_ASPNG;  P26922, TRPG_AZOBR;  
Q44696, TRPG_BUCAI;  P42388, TRPG_BUCAP;  Q89A30, TRPG_BUCBP;  
Q92411, TRPG_COCHE;  P06558, TRPG_CORGL;  P0CN87, TRPG_CRYNB;  
P27710, TRPG_CRYNH;  P0CN86, TRPG_CRYNJ;  O19914, TRPG_CYACA;  
P48261, TRPG_CYAPA;  P06531, TRPG_EMENI;  P71381, TRPG_HAEIN;  
Q9HPG6, TRPG_HALSA;  P33974, TRPG_HALVD;  Q9ZJU6, TRPG_HELPJ;  
O25868, TRPG_HELPY;  Q02003, TRPG_LACLA;  P20441, TRPG_LEPBI;  
Q57690, TRPG_METJA;  O27693, TRPG_METTH;  P26923, TRPG_METTM;  
P9WN34, TRPG_MYCTO;  P9WN35, TRPG_MYCTU;  Q1XDC5, TRPG_NEOYE;  
P00908, TRPG_NEUCR;  P24773, TRPG_PENCH;  P25170, TRPG_PHACH;  
P20409, TRPG_PHYBL;  P09575, TRPG_PICAN;  P51362, TRPG_PORPU;  
P20576, TRPG_PSEAE;  P00901, TRPG_PSEPU;  Q06129, TRPG_SACS2;  
Q92370, TRPG_SCHPO;  P00900, TRPG_SERMA;  P00906, TRPG_SHIDY;  
Q9YGB2, TRPG_THEKO;  P05379, TRPG_THET8;  Q9KST3, TRPG_VIBCH;  
P22101, TRPG_VIBPA;  P00937, TRPG_YEAST;  Q8ZEG6, TRPG_YERPE;  
P32069, TRPX_ARATH;  P44339, Y1171_HAEIN;  

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